Saving changes is not permitted. The changes you have made require the following tables to be dropped and re-created. You have either made changes to a table that can't be re-created or enabled the option Prevent saving changes that require the table to be re-created.
I ran into this fun little error message again tonight. It’s an annoying warning that pops up in SQL Server 2008 when performing certain changes to an existing schema. Apparently SQL Server 2008 drops and re-creates your tables when you make certain changes, so it keeps you from accidentally screwing up your database by providing this error. There is a setting which you can change to get around this “feature” but I highly recommend you think it through before just turning the warning off. After all, you wouldn’t want to inadvertently drop an important table would you?
To turn the warning off, go to Tools | Options | Designers | Table and Database Designers in SQL Server Management Studio and de-select the "Prevent saving changes that require table re-creation" checkbox.

You can also turn the setting off from Visual Studio by de-selecting the same checkbox in Tools |Options | Database Tools | Table and Database Designers | Table and Database Options.
Enjoy!